We study mechanisms of transduction and cellular communication in sensory and other cells. We develop transgenic mouse models and fluorescent reporters to visualize cell function in real time. We also analyze patterns of gene expression in complex tissues to understand the roles and differentiation of diverse cell types.

Calcium handling in the peripheral motor system and its disruption in neurodegenerative diseases

I am interested in the function of membrane proteins. In particular I am interested in transporters and channels and how the function of these proteins impact human physiology

Regulation of cell motility by Ca2+ and protein phosphorylation

Our lab uses the atomic force microscope to measure forces involved in biological processes, such as the adhesive events that occur during cell migration or during cell-cell interactions. Force measurements are also employed to elaborate on the energetics of vesicle fusion.

"My research concerns the physical mechanisms by which biological ion channels control their selectivity and ion flow. We use computational tools to address these questions at the atomic level."