Identify the attitudes and barriers towards Jewish genetic diseases among the young Jewish population of. Another project involves clinical research in Fragile X.

 

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I work on the statistical aspect of mapping genes for a variety of Mendelian and complex disorders. Among the disorders I am researching are: retinal diseases, deafness, club foot, cleft lip/palate, and stroke. In addition to mapping genes for deafness, I am also studying the effect that the unique mating structure of the deaf community has on the incidence of various forms of deafness. Lastly, I am also involved in genomic medicine and trying to integrate it into the private primary care setting.

 

Dr. Dykxhoorn is a molecular biologist interested in the role that small regulatory RNA molecules, microRNAs and small interfering RNAs, play in the pathogenesis of various diseases.

 

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Dr. Gilbert's research focuses on applications of genome technology to human genetics and the molecular genetics of autism, Alzheimer disease, Essential Tremor, and infectious disease such as tuberculosis. As a molecular biologist, his expertise is in gene analysis and characterization, positional cloning, mutation analysis, and animal models of human disorders.

 

 

Cell fate determination in the early Xenopus embryo with special emphasis on genetic mechanisms that preserve stem (germ) cell totipotency and promote cell migration.

Membrane Traffic: Sorting and regulation of protein transport in the endocytic and secretory pathways.

 

My research focuses on the use of molecular techniques, bioinformatics, and statistical methods to identify genetic variation and to characterize its role in disease susceptibility. I have been involved in studying a variety of neurological diseases including autism, Alzheimer disease, Parkinson disease, and multiple sclerosis.

 

Dr. Myers’s research focuses on the function of non-coding DNA variation within the human cortex with specific focus on the pathogenomic processes underlying late onset of Alzheimer.

 

Dr. Pericak-Vance excels at the integration of genomic and statistical technologies and their application to common and complex diseases of public health importance. Along with her research team, Dr. Pericak-Vance has identified risk genes for the amyotrophic lateral sclerosis, age-related macular degeneration, multiple sclerosis, autism, and Alzheimer disease.

 

Dr. Silva is interested in studying the central and peripheral mechanisms that control energy and glucose balance, the role of non-protein coding RNAs in metabolic gene regulation and strategies to target non-protein coding RNAs as drug therapies for obesity, diabetes and cardiovascular disease.

 

 

The goal of this laboratory is to increase our knowledge in the molecular mechanisms used by normal and cancer cells to keep the integrity of their telomeres and genomic DNA. Maintenance of genome stability depends on appropriate responses to DNA damage. This involves the mobilization of DNA damage factors to the site of damage and the activation of checkpoint pathways that consequently delay cell cycle progression. Lack of these controls results in an accumulation of chromosomes aberrations, genome instability and finally transformation. The natural ends of the linear chromosomes, the telomeres, represent a problem in the control of genome stability.

Dr. Walz's research focuses on understanding the molecular bases of human genetic conditions affecting behavior utilizing mouse models.

 

Dr. Young's research interests include epigenetic mechanisms regulating CNS function; mouse models of neurological diseases.