Research in the lab is focused on axon growth and guidance during development and regeneration

 

"My lab studies steroid hormone action in endocrine cancers. In particular, we focus on androgen and vitamin D regulation of oncogenesis in the prostate."

 

"We study survival and regeneration in the developing and adult nervous system, bridging molecular, cellular, and in vivo approaches. Additional projects focus on the use of stem cells and nanotechnology."

 

Cardiac cell regeneration

 

"The Cardiac Signal Transduction and Cellular Biology Laboratory at the University of Miami Miller School of Medicine is committed to the elucidation of the signal transduction pathways of the cardiac myocyte. In particular, we are interested in the role that multimolecular signaling complexes play is the regulation of myocyte function."

 

Cell fate determination in the early Xenopus embryo with special emphasis on genetic mechanisms that preserve stem (germ) cell totipotency and promote cell migration.

We are studying pathogenesis of lymphoma and biological processes in normal B cells

 

"Human Neuroanatomy, Addiction and Neurodegenerative diseases. Gene expression profiling and mapping in the human brain postmortem."

 

Computer-Aided Drug Design, semantic integration, cheminformatics, computational poly-pharmacology

 

Dr. Singal’s research focuses on the epigenetic mechanisms that inactivate certain tumor-suppressor genes in prostate cancer and designing clinical trials based on lab research.

 

"My research is directed toward unraveling the mechanisms of Familial Hypertrophic Cardiomyopathy (FHC), an autosomal dominant disease originating from mutations in genes that encode for the major contractile proteins of the heart, including the ventricular myosin regulatory (RLC) and essential (ELC) light chains. Using a combination of molecular biological and physiological approaches we are trying to answer important questions regarding the molecular determinants of the myosin light chain mutations - mediated pathology in the heart."

 

Dr. Wahlestedt's research interests focus on novel drug therapies for neuropsychiatric disorders and epigenetics.