University of Miami >> Miller School of Medicine >> Office of Graduate Studies >> Faculty Research >> Stem Cell/Regenerative Medicine

Stem Cell/Regenerative Medicine
Faculty MemberContact
Mary  Bartlett Bunge, Ph.D. Mary Bartlett Bunge, Ph.D.
Christine E. Lynn Distinguished Professor in Neuroscience, Professor, Cell Biology, Neurological Surgery, and Neurology
Research Summary
Development of combination strategies to repair the injured spinal cord
(305) 243-4596 (ph)
Lois Pope LIFE Center 5-18
Nanette  Bishopric, M.D., F.A.C.C. Nanette Bishopric, M.D., F.A.C.C.
Professor of Pharmacology and Medicine
Research Summary
"Cardiac myocyte growth and death, transcriptional and post-transcriptional control of cell growth"
305-243-6775 (ph)
305-243-6082 (fax)
Rosenstiel Medical Sciences Building 6038
M. Ross  Bullock, M.D., Ph.D. M. Ross Bullock, M.D., Ph.D.
Professor, Neurological Surgery and Director, Clinical Neurotrauma
Research Summary
(305) 243-4456 (ph)
Lois Pope LIFE Center - 3rd Floor
Juan  Dominguez-Bendala, Ph.D. Juan Dominguez-Bendala, Ph.D.
Research Associate Professor of Diabetes Research Institute/Surgery and Cell Biology
Research Summary
The main lines of research at my laboratory revolve around the development of regenerative strategies for type 1 diabetes, which include islet regeneration, reprogramming/transdifferentiation andstem celldifferentiation into insulin-producing beta cells. In the context of the latter, we haveconducted seminal studieson the use of protein transduction and the role of oxygenation on pancreatic endocrinedevelopment. Our lab was among the first to conduct research on human embryonic stem cells at the University of Miami.
305-243-4092 (ph)
DRI room 5008
Mohammad  Faghihi, M.D., Ph.D. Mohammad Faghihi, M.D., Ph.D.
Assistant Professor of Psychiatry & Behavioral Sciences, Neuroscience Program Affiliated Faculty Member, Full Member of Center on Aging, Member of Hussman Institute for Human Genomics, Founding Member of Center for Therapeutic Innovations
Research Summary
The main focus of my lab is the study of regulatory long noncoding RNAs and their involvement in neurological and neuropsychological disorders such as:

Alzheimer’s disease, Parkinson’s disease
Multiple Sclerosis
Fragile X Syndrome, Autism

We are interested in understanding the mechanisms of long noncoding RNA function in the context of gene expression regulation, chromatin modifications and epigenetics.

We are interested in epigenetics, DNA methylation, chromatin modifications and induction of these changes by noncoding RNAs
We also study interactions between RNA molecules and proteins to probe their functions.

The overall goal of the lab is to identify disease-specific long noncoding RNAs that can be used as:

1- Biomarkers (Identifying RNA biomarkers for early diagnosis)

2- Novel therapeutic targets (Identifying noncoding pathologic agents to find novel therapeutic targets)
View Collexis Profile
305-243-7953 (ph)
305-243-2769 (fax)
Biomedical Research Building
James D. Guest, M.D., Ph.D. James D. Guest, M.D., Ph.D.
Associate Professor, Neurological Surgery
Research Summary
Glial cell transplantation to repair long tract injury in primates. Dedifferentiation of neuroblastoma in reponse to hypoxia
305-243-6946 (ph)
Lois Pope LIFE Center 5-17
Joshua M.  Hare, M.D. Joshua M. Hare, M.D.
Professor, Molecular and Cellular Pharmacology, Louis Lemberg Professor of Medicine, Chief of Cardiology, Director, Interdisciplinary Stem Cell Institute
Research Summary
Cardiac cell regeneration
305-243-1998 (ph)
Clinical Research Building, Room 1124, 1120 NW 14th St. Miami, FL 33136
Guy A. Howard, Ph.D. Guy A. Howard, Ph.D.
Professor of Medicine and Biochemistry & Molecular Biology; Research Director - GRECC Miami VA Med Center
Research Summary
Cell and molecular biology of bone; cell and molecular biology of aging; stem cells and reparative medicine
305-575-3388 (ph)
VA Med Center, CLC-207
Tan A. Ince, M.D., Ph.D. Tan A. Ince, M.D., Ph.D.
Associate Professor of Pathology
Research Summary
The research in my laboratory focuses on the role of normal cell-of-origin in determining tumor phenotype and tumor stem cell biology.  In addition we are involved in development of culture systems for in vitro culture of primary human tissues and tumors, as well as development of xenograft tumor models.  As a surgical pathologist I am also involved in several translational research projects in breast and ovarian cancer.
305-243-1782 (ph)
Biomedical Research Building (BRB) Room 913
Michael S.  Kapiloff, M.D., Ph.D. Michael S. Kapiloff, M.D., Ph.D.
Associate Professor, Departments of Medicine and Pediatrics and. Director, Cardiac Signal Transduction and Cellular Biology Laboratory
Research Summary
"The Cardiac Signal Transduction and Cellular Biology Laboratory at the University of Miami Miller School of Medicine is committed to the elucidation of the signal transduction pathways of the cardiac myocyte. In particular, we are interested in the role that multimolecular signaling complexes play is the regulation of myocyte function."
305-243-7863 (ph)
305-243-3906 (fax)
Biomedical Research Building, Room 810
Vance  Lemmon, Ph.D. Vance Lemmon, Ph.D.
Walter G. Ross Distinguished Chair in Developmental Neuroscience
Research Summary
Our lab studies axon regeneration in vitro and in vivo. A major goal is to identify and characterize genes that enhance axon regeneration using high content screening.
Robert B. Levy, Ph.D. Robert B. Levy, Ph.D.
Professor of Microbiology and Immunology
Research Summary
We are interested in understanding how T lymphocytes: a) control the process of hematopoietic progenitor cell engraftment following marrow / blood transplantation and b) mediate anti-tumor immunity against malignancies in individuals post-transplant.
305-243-4542 (ph)
305-243-8595 (fax)
Room 720, McKnight Building
Daniel  Liebl, Ph.D. Daniel Liebl, Ph.D.
Professor, Neurological Surgery
Research Summary
Research in the lab focuses on axon growth and guidance in the developing and regenerating nervous systems. Neural stem/progenitor cell biology in both native neurogenesis and following CNS trauma using endogenous and transplantation strategies
(305) 243-7143 (ph)
Lois Pope LIFE Center 3-16
Savita  Pahwa, M.D. Savita Pahwa, M.D.
Professor, Microbiology & Immunology (Pediatrics and Medicine Director, Miami CFAR (Center for AIDS Research)
Research Summary
I am a physician scientist, pediatrician and immunologist with expertise in human immunology.  My clinical and research background is in Primary Immune Deficiency Diseases and HIV/AIDS.  Over the past several years my research focus has been in immunopathogenesis of HIV/AIDS in children with vertical transmission of HIV-1 and adults with behaviorally transmitted infection.  Advances in combination antiretroviral therapy (cART) have changed HIV/AIDS from an acute fatal infection to one of survival and controlled virus replication but requires daily life-long treatment medications and is complicated by early development of diseases associated with aging.  Currently, my research efforts are directed at understanding the spectrum of immune defects that persist despite virologic control in HIV/AIDS across different ages, from childhood to old age. I am interested in the role of immune activation and inflammation in causing immune dysfunction and end organ diseases, use of influenza vaccine as a probe to evaluate immune competence/ immunologic impairment, role of T follicular helper cells and interleukin 21 in antibody responses, mechanisms of persistence of HIV-1 in “reservoirs” despite ART, vaccines for HIV-1 prevention and immunotherapeutic strategies to achieve a cure for HIV/AIDS.  At University of Miami I am the Director of the Miami Center for AIDS Research (Miami CFAR) and I also direct the CFAR’s Laboratory Sciences Core (Core D). I have expertise in advanced immunophenotyping for cell surface markers and intracellular molecules by flow cytometry using 14 color panels, B cell functions, Luminex assays for cytokines, gut microbial translocation assays, transcription factors and cellular pathways. At the University of Miami I work closely with investigators engaged in HIV clinical programs to address pathogenesis questions in clinical trials. 
305-243-7732 (ph)
305-243-7211 (fax)
Room 712 (office), 708 (lab) Batchelor Children's Research Institute
Kevin  Park, PhD Kevin Park, PhD
Assistant Professor of Neurological Surgery
Research Summary
To understand the neuron’s intrinsic mechanisms that account for failure of axon regeneration in the central nervous system (CNS). Previously, we have identified several key proteins that block axon regeneration, which are present in mature CNS neurons.  We hope to further extend the findings in order to better understand the mechanisms governing axon regeneration and also to explore the potential of developing therapeutic strategies for CNS injuries. 
305-243-2493 (ph)
Lois Pope LIFE Center 4-20
Damien  Pearse, Ph.D. Damien Pearse, Ph.D.
Associate Professor, Neurological Surgery
Research Summary
"My laboratory focuses on several key aspects of CNS injury repair: 1) preventing progressive tissue damage following the initial mechanical trauma through the application of pharmacological or biological neuroprotectants, 2) overcoming the physical impediment of the injury cyst through the implantation of exogenous cells or by harnessing endogenous cellular repair mechanisms and, 3) the promotion of axon regeneration by the stimulation of intracellular signaling pathways that are important in the initiation and/or maintainence of axon growth."
(305) 243-7139 (ph)
Lois Pope LIFE Center 5-15
Jacqueline  Sagen, Ph.D. Jacqueline Sagen, Ph.D.
Professor, Neurological Surgery
Research Summary
Our laboratory is exploring the potential for cell transplantation and/or gene therapy to alleviate chronic pain.
(305) 243-5618 (ph)
Lois Pope LIFE Center 5-14
Paul  Schiller, Ph.D. Paul Schiller, Ph.D.
Research Associate Professor of Medicine
Research Summary
"Marrow-isolated adult mutilineage inducible (MIAMI) stem cells: molecular mechanisms of self-renewal, proliferation and differentiation; and their use in regenerative medicine."
Lina  Shehadeh, Ph.D. Lina Shehadeh, Ph.D.
Assistant Professor of Medicine
Research Summary
MicroRNAs in treating atherosclerosis and inducing cardiac regeneration.
Aptamer-microRNA chimera for targeted delivery of microRNAs.
305-243-0867 (ph)
305-243-3906 (fax)
BRB 818 (Office); BRB 848 FG (Lab)
Vladlen Z.  Slepak, Ph.D. Vladlen Z. Slepak, Ph.D.
Professor and Graduate Program Director, Molecular and Cellular Pharmacology
Research Summary
"Novel mechanisms of signal transduction, with a focus on heterotrimeric G proteins and Ca2+ binding proteins. Structure-function aspects and subcellular localization of signaling proteins"
305-243-3430 (ph)
305-243-4555 (fax)
Rosenstiel Medical Sciences Building 6008
Christine  Thomas, Ph.D. Christine Thomas, Ph.D.
Professor, Neurological Surgery
Research Summary
"My research explores strategies to rescue denervated muscles from degeneration; the mechanisms underlying peripheral nerve regeneration, neuromuscular fatigue, weakness and spasticity."
305-243-7109 (fax)
Lois Pope LIFE Center Lois Pope LIFE Center
Pantelis  Tsoulfas, M.D. Pantelis Tsoulfas, M.D.
Associate Professor, Neurological Surgery and Cell Biology
Research Summary
"Our areas of research center on the development of the nervous system, neurotrophin signaling in neural cells and repair of the CNS after spinal cord injury. For the development of nervous system we try to understand how mitogenic factors influence cell numbers and how cell fates are linked to specific transcriptional networks. We use live fluorescent imaging techniques to study neurotrophin signaling. For spinal cord injury repair strategies, we utilize modified neurotrophins and grafting of CNS derived cells. We integrate several approaches including Cell Biology, Molecular Biology, Biochemistry, Genetics and Imaging techniques."
(305) 243 3433 (ph)
(305) 243 3434 (fax)
Lois Pope LIFE Center 5-13
Claes  R.  Wahlestedt, M.D, Ph.D. Claes R. Wahlestedt, M.D, Ph.D.
Director, Genomic Interdisciplinary Therapeutic Innovation Center (G-ITIC)
Research Summary
Dr. Wahlestedt's research interests focus on novel drug therapies for neuropsychiatric disorders and epigenetics.
305-243-7694 (ph)
305-243-2396 (fax)
Room 407, Biomedical Research Building
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