Faculty Research : Faculty Research Detail

Keith Webster, Ph.D.

Professor of Molecular and Cellular Pharmacology; Director of the Vascular Biology Institute; Walter G. Ross Chair of Vascular Biology

305-243-6779 (office)

305-243-6082 (fax)

Rosenstiel Medical Sciences Building 6038

kwebster@med.miami.edu

Curriculum Vitae

B. A. in Biology , University of York, England

Ph.D. in Biochemistry, University of York, England

Senior Research Associate, Dept. of Genetics, Stanford University, California.

Assistant Professor, Dept of Biochemistry, USC, Los Angeles, Calif. (1988)

Senior Scientist, SRI International (1993)

Program Director, Molecular Cardiology Laboratory, SRI International, (1996)

Associate Professor, University of Miami , Miami, FL. (1998)

President & CEO of Integene Inc. (Intelligent Gene and Cell Therapy)

Research Interests

Molecular mechanisms of hypoxia/ischemia-regulated gene expression.
Molecular pathology of vascular disease.
Control of cell death in ischemic heart disease/protective strategies.
Gene therapy with "Intelligent Gene" delivery techniques.

MOLECULAR CARDIOLOGY

Keith A. Webster, Ph. D
Nanette H. Bishopric, M

The Molecular Cardiology Laboratory at the University of Miami has active research projects in the following areas:

cardiac-specific transcriptional regulation
cardiac stress responses/apoptosis
hypoxia, ischemia, and redox-associated cell damage
cardiac cell cycle protein interactions
genetic regulation of cardiac hypertrophy
cardiac gene transfer
gene therapy: see under InteGene site

Applicable techniques include molecular biology, immunocytochemistry, laser imaging, motion analysis, protein chemistry, gene-chip array screening, viral gene transfer, apoptosis assays, animal models of heart failure.

Recent Publications

Chopra I, Li HF, Wang H, Webster KA. Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle. Diabetologia. 2012 Mar;55(3):783-94. Epub 2011 Dec 30. PMID: 22207502

Shehadeh LA, Webster KA, Hare JM, Vazquez-Padron RI. Dynamic regulation of vascular myosin light chain (MYL9) with injury and aging. PLoS One. 2011;6(10):e25855. Epub 2011 Oct 7.PMID: 22003410

Xu Q, Wang J, He J, Zhou M, Adi J, Webster KA, Yu H. Impaired CXCR4 expression and cell engraftment of bone marrow-derived cells from aged atherogenic mice. Atherosclerosis. 2011 Nov;219(1):92-9. Epub 2011 Aug 4. PMID: 21855069

Jia P, Zhang C, Jia Y, Webster KA, Huang X, Kochegarov AA, Lemanski SL, Lemanski LF. Identification of a truncated form of Methionine Sulfoxide Reductase A expressed in mouse embryonic stem cells. J Biomed Sci. 2011 Jun 22;18:46. PMID: 21696616

Cesar L, Suarez SV, Adi J, Adi N, Vazquez-Padron R, Yu H, Ma Q, Goldschmidt-Clermont PJ, Agatston A, Kurlansky P, Webster KA. An essential role for diet in exercise-mediated protection against dyslipidemia, inflammation and atherosclerosis in ApoE⁻/⁻ mice. PLoS One. 2011 Feb 16;6(2):e17263. PMID: 21359188

Wei J, Wang W, Chopra I, Li HF, Dougherty CJ, Adi J, Adi N, Wang H, Webster KA. c-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction. J Biol Chem. 2011 Apr 22;286(16):13995-4006. Epub 2011 Feb 15. PMID: 21324895

Shao H, Xu Q, Wu Q, Ma Q, Salgueiro L, Wang J, Eton D, Webster KA, Yu H. Defective CXCR4 expression in aged bone marrow cells impairs vascular regeneration. J Cell Mol Med. 2011 Oct;15(10):2046-56. doi: 10.1111/j.1582-4934.2010.01231.x. PMID: 21143386

Zhang C, Jia P, Jia Y, Li Y, Webster KA, Huang X, Achary M, Lemanski SL, Lemanski LF. Anoxia, acidosis, and intergenic interactions selectively regulate methionine sulfoxide reductase transcriptions in mouse embryonic stem cells. J Cell Biochem. 2011 Jan;112(1):98-106.PMID: 20872796

Vazquez-Padron RI, Mateu D, Rodriguez-Menocal L, Wei Y, Webster KA, Pham SM. Novel role of Egr-1 in nicotine-related neointimal formation. Cardiovasc Res. 2010 Nov 1;88(2):296-303. Epub 2010 Jul 8. PMID: 20615913

Zhang C, Jia P, Jia Y, Weissbach H, Webster KA, Huang X, Lemanski SL, Achary M, Lemanski LF. Methionine sulfoxide reductase A (MsrA) protects cultured mouse embryonic stem cells from H2O2-mediated oxidative stress. J Cell Biochem. 2010 Sep 1;111(1):94-103. PMID: 20506347

Wu Q, Ma Q, Shehadeh LA, Wilson A, Xia L, Yu H, Webster KA. Expression of the Argonaute protein PiwiL2 and piRNAs in adult mouse mesenchymal stem cells. Biochem Biophys Res Commun. 2010 Jun 11;396(4):915-20. Epub 2010 May 10. PMID: 20460113

Wilson A, Shehadeh LA, Yu H, Webster KA. Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells. BMC Genomics. 2010 Apr 7;11:229. PMID: 20374652

Back to Previous Page