University of Miami >> Miller School of Medicine >> Office of Graduate Studies >> Faculty Research >> Faculty Research Detail

Feng Gong, Ph.D.

Associate Professor, Department of Biochemistry & Molecular Biology

(305) 243-9270 (office)

(305) 243-3955 (fax)

Gautier Room 303

fgong@med.miami.edu


Curriculum Vitae
Ph.D.  (1998) The Chinese Academy of Sciences, China.
Postdoctoral Research: Stanford University
 
 

Research Interests
Dr. Gong's research focus is to understand how DNA repair pathways operate in eukaryotic cells to remove DNA lesions from chromatin. His laboratory is using budding yeast and cultured human cells to examine the role of histone modifications and chromatin remodeling in DNA repair.
 


Maintenance of genomic integrity is of fundamental importance to all living organisms. Defects in DNA repair are found in human diseases associated with increased cancer frequency. Nucleotide excision repair (NER) is a DNA repair pathway found in all organisms that removes a wide variety of bulky DNA adducts. In eukaryotic cells, DNA is packaged with histones and other accessory proteins into chromatin. Thus DNA repair enzymes must deal with the highly compact and dynamic structure of chromatin. Recently, we have found evidence that the SWI/SNF chromatin remodeling complex plays an important role to facilitate NER.

Several subunits of the human SWI/SNF complex are encoded by tumor suppressor genes. We are currently investigating the mechanisms by which SWI/SNF remodel nucleosomes to facilitate NER. Our laboratory employs mammalian cell culture and budding yeast as model systems to address basic questions concerning the regulation/or modification of chromatin in response to DNA damage.

 

Recent Publications
1) L. Zhang, Q. Zhang, K. Jones, M. Patel and F. Gong. 2009. The chromatin remodeling factor BRG1 stimulates nucleotide excision repair by facilitating recruitment of XPC to sites of DNA damage. Cell Cycle. 8(23). Epub
 
2) F. Gong, D. Fahy, H. Liu, W. Wang and M. Smerdon. 2008. Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage. Cell Cycle 7(8): 1069-1076.
 
3) F. Gong, D. Fahy and M. Smerdon. 2006. Rad4–Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repair. Nature Structural & Molecular Biology 13: 902 – 907 (paper of the month).
 
4) F. Gong and C. Yanofsky. 2002. Instruction of translating ribosome by nascent peptide. Science, 297: 1864-7.
 

5) F. Gong, K. Ito, Y. Nakamura and C. Yanofsky. 2001. The mechanism of tryptophan induction of tryptophanase operon expression: tryptophan inhibits release factor 2 mediated cleavage of TnaC-peptidyl-tRNAPro. Proc. Natl. Acad. Sci. USA, 98(16): 8997-9001.

 


 
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