We use fluorescent indicator dyes and a confocal microscope system to study changes in cytosolic and mitochondrial [Ca2+], mitochondrial membrane potential and vesicular release in motor terminals.

 

sensory perception and neurodegeneration

 

Dr. Dahl’s research interests concentrate on ways of intercellular communication through gap junctions and calcium waves. Presently the focus is on the role of pannexin channels as ATP release pathway.

 

I am interested in the function of membrane proteins. In particular I am interested in transporters and channels and how the function of these proteins impact human physiology

 

Our research centers around the elucidation of mechanisms of genetic retinal diseases that lead to blindness through the identification of the causative genes, construction and use of animal models to elucidate the pathophysiological mechanisms by which specific gene mutations lead to retinal degeneration, and therapeutic manipulation of the animal models with the ultimate goal of developing effective therapies.

 

Regulation of cell motility by Ca2+ and protein phosphorylation

 

Molecular mechanisms of voltage-gated ion channels and neurotransmitter transporters, using electrophysiology and fluorescence techniques.

 

Our lab uses the atomic force microscope to measure forces involved in biological processes, such as the adhesive events that occur during cell migration or during cell-cell interactions. Force measurements are also employed to elaborate on the energetics of vesicle fusion.

 

"My research concerns the physical mechanisms by which biological ion channels control their selectivity and ion flow. We use computational tools to address these questions at the atomic level."