Olfaction, olfactory receptors and ligands
Cancer cell biology and metabolism

 

Research in the lab is focused on axon growth and guidance during development and regeneration

 

"Computer-aided drug design, small molecule modulators of the costimulatory protein-protein interaction, immunomodulation for islet transplantation"

 

 

Membrane Traffic: Sorting and regulation of protein transport in the endocytic and secretory pathways.

 

"We study how intracellular mediators interact to regulate signal output by G protein coupled receptors (GPCR). Understanding how GPCR signaling is regulated, in health and disease, can lead to new therapeutic strategies."

 

Computer-Aided Drug Design, semantic integration, cheminformatics, computational poly-pharmacology

 

"My research is directed toward unraveling the mechanisms of Familial Hypertrophic Cardiomyopathy (FHC), an autosomal dominant disease originating from mutations in genes that encode for the major contractile proteins of the heart, including the ventricular myosin regulatory (RLC) and essential (ELC) light chains. Using a combination of molecular biological and physiological approaches we are trying to answer important questions regarding the molecular determinants of the myosin light chain mutations - mediated pathology in the heart."